Acyclovir/​Lidocaine/​Hydrocortisone

Adding hydrocortisone, a corticosteroid that calms inflammation, and lidocaine, a local anesthetic that numbs the area, this cream builds on acyclovir's antiviral action against herpes simplex virus. It is commonly used to address cold sore and herpes simplex outbreaks while relieving the pain, itching, and swelling that often go with them.